Teenager Paul McLeod started the rout after nodding home Derek Fleming's corner from the right on five minutes.
There was little evidence at that stage of the drubbing to come and Queens even had an equaliser disallowed when Derek Lyle was adjudged to be offside.
On 31 minutes Fleming put Hamilton two ahead from the penalty spot after Paul Burns had brought down Paul McMullan.
Four minutes later Fleming's free kick was parried by Colin Scott allowing McLeod to smash home his second from the rebound.
There was a brief glimmer of home for Queens when John O'Neill converted a penalty on 45 minutes but few doubted the eventual outcome of the match.
A home win was assured on 53 minutes when McMullan's cross from the left drifted over Scott's head to land in the net.
Five minutes later O'Neill scored his second after Lyle flicked on Eric Paton's free-kick.
However, any hopes Queens might have had were dashed when Brian McColligan was send off for a second bookable offence on 63 minutes.
Things got even worse when the referee adjudged a deflection from Gary Wood to be a pass back.
Brown Ferguson tucked the ball home from Fleming's indirect free-kick to complete Ian McCall's misery.